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Name |
Benazepril |
Synonyms |
Benazeprilum;Benazepril [INN:BAN];2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;Benazeprilum [Latin];(3S)-1-(carboxymethyl)-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one;benzazepril |
Molecular Formula |
C24H28N2O5 |
Molecular Weight |
424.49000 |
CAS Number |
86541-75-5 |
purity |
≥98% |
Storage conditions |
Sealed in dry,2-8°C |
Application:Benazepril (CAS No.: 86541-75-5), brand name Lotensin
(Novartis), is an ACE inhibitor used primarily in treatment of hypertension,
congestive heart failure, and heart attacks, and also in preventing the renal
and retinal complications of diabetes.
ACE inhibitors relax blood vessels, and decrease
blood volume, which lowers blood pressure and decreases oxygen demand from the
heart. They inhibit angiotensin-converting enzyme, which is part of the renin–angiotensin–aldosterone
system.
Benazepril is a prodrug which is metabolized by
the liver into its active form benazeprilat via cleavage of the drug's ester
group.